Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Abstract

The choriocapillaris (CC) represents a fundamentally important vascular layer that is subject to physiologic changes with increasing age and that is also associated with a wide range of chorioretinal diseases. So far, information on blood flow in this specific layer has remained limited. With the advent of optical coherence tomography angiography (OCTA), new perspectives and possibilities of CC imaging have begun to evolve. This article shall review the opportunities and challenges of applying OCTA technology to the CC layer and summarize the current clinical efforts in OCTA CC imaging exemplarily in dry age-related macular degeneration and central serous chorioretinopathy.

Keywords: Age-related macular degeneration; Central serous chorioretinopathy; Choriocapillaris; Optical coherence tomography; Optical coherence tomography angiography; Spectral-domain optical coherence tomography; Swept-source optical coherence tomography.