A novel approach for fabricating nanocomposite materials by embedding stabilized core-shell micelles into polysaccharide cryogel matrix

Viktoria Pencheva; Elena Margaritova; Maria Borinarova; Marta Slavkova; Denitsa Momekova; Petar D Petrov

doi:10.1016/j.carbpol.2017.12.016

A novel approach for fabricating nanocomposite materials by embedding stabilized core-shell micelles into polysaccharide cryogel matrix

Carbohydr Polym. 2018 Mar 1:183:165-172. doi: 10.1016/j.carbpol.2017.12.016. Epub 2017 Dec 11.

Authors

Viktoria Pencheva¹, Elena Margaritova², Maria Borinarova³, Marta Slavkova⁴, Denitsa Momekova⁵, Petar D Petrov⁶

Affiliations

¹ Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev Street 103A, 1113, Sofia, Bulgaria; Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria. Electronic address: viktoria.pencheva07@gmail.com.
² Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev Street 103A, 1113, Sofia, Bulgaria; Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria. Electronic address: margo94sm@abv.bg.
³ Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev Street 103A, 1113, Sofia, Bulgaria; Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria. Electronic address: mimity_9411@abv.bg.
⁴ Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria. Electronic address: marta.iv.slavkova@gmail.com.
⁵ Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Street, 1000, Sofia, Bulgaria. Electronic address: dmomekova@pharmfac.acad.bg.
⁶ Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev Street 103A, 1113, Sofia, Bulgaria. Electronic address: ppetrov@polymer.bas.bg.

PMID: 29352871
DOI: 10.1016/j.carbpol.2017.12.016

Abstract

We report a novel approach for fabricating nanocomposite polysaccharide-based carriers for sustained delivery of poorly-water-soluble drugs by embedding stabilized core-shell micelles (SPM) possessing hydrophobic cores into super-macroporous hydroxypropyl cellulose (HPC) cryogels. Firstly, nano-sized SPM were synthesized by loading and photochemical crosslinking of pentaerythritoltetraacrylate (PETA) in poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO₁₉PPO₂₉PEO₁₉) core-shell micelles. Next, HPC cryogels containing different amount of SPM were fabricated by combination of cryogenic treatment and photo-crosslinking. A crosslinking agent, N,N'-methylenebisacrylamide, was used to enhance the density of polymer network. The effect of SPM concentration on gel fraction yield, swelling degree, cryogel morphology and mechanical properties were studied. Nanocomposite cryogels were loaded with curcumin and their encapsulation efficiency and drug release profile as a function of SPM content were investigated. The cytotoxic effect of blank and curcumin loaded nanocomposite cryogels was assessed as well.

Keywords: Cryogels; Curcumin; Drug carriers; Nanocomposites; Polymeric micelles.

MeSH terms

Acrylamides / chemistry
Cell Line, Tumor
Cellulose / analogs & derivatives*
Cryogels / chemistry*
Curcumin / administration & dosage
Drug Carriers / chemistry
HEK293 Cells
Humans
Methacrylates / chemistry
Micelles*
Nanocomposites / adverse effects
Nanocomposites / chemistry*
Polyethylene Glycols / chemistry
Propylene Glycols / chemistry

Substances

Acrylamides
Cryogels
Drug Carriers
Methacrylates
Micelles
PEO-PPO-PEO
Propylene Glycols
pentaerythritol monomethacrylate
Polyethylene Glycols
Cellulose
N,N'-methylenebisacrylamide
Curcumin