Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people

Hengxin Li; Jun Chen; RuiZhi Zhang; Ran Xu; Zhe Zhang; Le Ren; Qi Yang; Yumei Tian; Daxu Li

doi:10.18632/oncotarget.19669

Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people

Oncotarget. 2017 Jul 28;8(68):112451-112459. doi: 10.18632/oncotarget.19669. eCollection 2017 Dec 22.

Authors

Hengxin Li^#¹, Jun Chen^#², RuiZhi Zhang³, Ran Xu⁴, Zhe Zhang⁴, Le Ren⁴, Qi Yang^{5

6}, Yumei Tian⁷, Daxu Li³

Affiliations

¹ Xi'an Center for Disease Control and Prevention, Xi'an, Shaanxi 710054, China.
² Department of Pharmacy, The Ankang Central Hospital, Ankang, Shaanxi 725000, China.
³ Department of Stomatology, The Ankang Central Hospital, Ankang, Shaanxi 725000, China.
⁴ Department of Stomatology, The First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
⁵ Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
⁶ Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
⁷ Xi'an Mental Health Center, Xi'an, Shaanxi 710061, China.

^# Contributed equally.

Abstract

Single nucleotide polymorphisms (SNPs) in ZNF208 may be associated with susceptibility to Hepatitis B virus (HBV). In the current study, we analyzed the association between ZNF208 SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi'an area of Chinese Han Population. Of the five SNPs examined, rs2188971 (OR: 1.36, 95% CI: 1.04-1.76, P = 0.022), rs8103163 (OR: 1.40, 95% CI: 1.08-1.82, P = 0.010) and rs7248488 (OR: 1.38, 95% CI: 1.07-1.79, P = 0.014) were correlated with HBV susceptibility based on Chi-square tests. After the P-values were adjusted by Bonferroni correction, there only rs8103163 (P = 0.050) was slightly with increased HBV risk. Additionally, haplotype A_rs2188972T_rs2188971A_rs8103163A_rs7248488 (OR = 1.42; 95% C I, 1.10-1.85; P = 0.008) was found to increase susceptibility of suffering from HBV. These findings suggest that ZNF208 polymorphisms may contribute to the development of HBV.

Keywords: Chinese Han population; HBV; SNPs; ZNF208; susceptibility.