The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function

Exerc Sport Sci Rev. 2018 Apr;46(2):92-96. doi: 10.1249/JES.0000000000000142.

Abstract

The Hippo signaling pathway regulates the activity of the proteins Yes-associated protein (Yap) and transcriptional co-activator with PDZ-binding motif (Taz) to control tissue growth in many different cell types. Previously, we demonstrated that Yap is a critical regulator of skeletal muscle mass. We hypothesize that alterations in Yap and Taz activity modulate the anabolic adaptations of skeletal muscle to resistance exercise.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological
  • Cell Cycle Proteins
  • DNA-Binding Proteins / metabolism
  • Gene Expression
  • Hippo Signaling Pathway
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Muscle Fibers, Skeletal / metabolism
  • Muscle, Skeletal / anatomy & histology*
  • Muscle, Skeletal / growth & development
  • Muscle, Skeletal / metabolism*
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Protein Serine-Threonine Kinases / metabolism*
  • Resistance Training*
  • Signal Transduction*
  • TEA Domain Transcription Factors
  • Trans-Activators
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcriptional Coactivator with PDZ-Binding Motif Proteins

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • Nuclear Proteins
  • TEA Domain Transcription Factors
  • TEAD1 protein, human
  • Trans-Activators
  • Transcription Factors
  • Transcriptional Coactivator with PDZ-Binding Motif Proteins
  • WWTR1 protein, human
  • YY1AP1 protein, human
  • Protein Serine-Threonine Kinases