In vivo osteoconductivity of surface modified Ti-29Nb-13Ta-4.6Zr alloy with low dissolution of toxic trace elements

Eri Takematsu; Kimihiro Noguchi; Kensuke Kuroda; Toshiyuki Ikoma; Mitsuo Niinomi; Nobuhiro Matsushita

doi:10.1371/journal.pone.0189967

In vivo osteoconductivity of surface modified Ti-29Nb-13Ta-4.6Zr alloy with low dissolution of toxic trace elements

PLoS One. 2018 Jan 17;13(1):e0189967. doi: 10.1371/journal.pone.0189967. eCollection 2018.

Authors

Eri Takematsu¹, Kimihiro Noguchi², Kensuke Kuroda³, Toshiyuki Ikoma⁴, Mitsuo Niinomi^{3

5

6}, Nobuhiro Matsushita⁴

Affiliations

¹ Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas, United States of America.
² Department of Mathematics, Western Washington University, Bellingham, Washington, United States of America.
³ Institute of Materials and Systems for Sustainability, Nagoya University, Chikusa, Nagoya, Japan.
⁴ Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, Meguro, Tokyo, Japan.
⁵ Institute for Materials Research, Tohoku University, Aoba-ku, Sendai, Japan.
⁶ Department of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan.

Abstract

Simulated Body Fluid (SBF) has served as a useful standard to check the bioactivity of implant materials for years. However, it is not perfectly able to imitate human serum; sometimes disparities between the SBF test and animal test were confirmed. Therefore, to ensure the reliability of the results of the SBF test obtained from our previous study, an animal study was performed to check osteoconductivity of surface modified implant materials. Three types of solution processes, hydrothermal (H), electrochemical (E), and hydrothermal-electrochemical (HE), were performed on the Ti-29Nb-13Ta-4.6Zr alloy (TNTZ) to improve its bioactivity, and their bioactivities were measured in vivo using bone-implant contacts (BICs). BICs of the HE- and H-treated samples were significantly higher than that of the control. Metal ion diffusion towards the bone was also evaluated to examine the adverse effect of metal ions. No metal ion diffusion was observed, indicating the safety of our solution processed implant materials.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Regeneration*
Niobium / chemistry*
Rats
Rats, Sprague-Dawley
Solubility
Tantalum / chemistry*
Titanium / chemistry*
Trace Elements / pharmacokinetics*
Zirconium / chemistry*

Substances

Ti-29Nb-13Ta-4.6Zr alloy
Trace Elements
Niobium
Tantalum
Zirconium
Titanium

Grants and funding

This research was funded by a grant from the Collaboration Research Project of Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials supported by MEXT as well as the collaborative research of the Institute for Materials Research at Tohoku University (http://www.msl.titech.ac.jp/english/member/six_institutes.html; http://www.imr.tohoku.ac.jp/en/).