1H Spectroscopic Imaging of the Rodent Brain

Rui V Simões; Emma Muñoz-Moreno; Raúl Tudela; Guadalupe Soria

doi:10.1007/978-1-4939-7531-0_12

¹H Spectroscopic Imaging of the Rodent Brain

Methods Mol Biol. 2018:1718:189-202. doi: 10.1007/978-1-4939-7531-0_12.

Authors

Rui V Simões^{1

2}, Emma Muñoz-Moreno³, Raúl Tudela⁴, Guadalupe Soria^{3

4}

Affiliations

¹ Fetal i+D Fetal Medicine Research Center, BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia, Obstetricia i Neonatologia, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain. portasferre@clinic.ub.es.
² Champalimaud Foundation, Lisbon, Portugal. portasferre@clinic.ub.es.
³ Experimental 7T MRI Unit, IDIBAPS, Barcelona, Spain.
⁴ Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain.

PMID: 29341010
DOI: 10.1007/978-1-4939-7531-0_12

Abstract

Proton MR spectroscopic imaging (MRSI) can provide a variety of "molecular images" from animal models of human disease, which are useful for different research purposes. This chapter describes a protocol for in vivo acquisition and analysis of MRSI data from the rodent brain.

Keywords: Acquisition-weighting; Chemical shift imaging (CSI); Field of view (FOV); Magnetic Resonance Spectroscopic Imaging (MRSI); Point resolved spectroscopy (PRESS); Spectral analysis; Volume of interest (VOI).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / metabolism*
Functional Neuroimaging / methods*
Hydrogen / metabolism*
Image Processing, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Proton Magnetic Resonance Spectroscopy / methods*
Rodentia

Substances

Hydrogen