In Vivo 1H Magnetic Resonance Spectroscopy

M Carmen Muñoz-Hernández; María Luisa García-Martín

doi:10.1007/978-1-4939-7531-0_10

In Vivo ¹H Magnetic Resonance Spectroscopy

Methods Mol Biol. 2018:1718:151-167. doi: 10.1007/978-1-4939-7531-0_10.

Authors

M Carmen Muñoz-Hernández¹, María Luisa García-Martín^{2

3}

Affiliations

¹ BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain.
² BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain. mlagarcia@bionand.es.
³ Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Málaga, Spain. mlagarcia@bionand.es.

PMID: 29341008
DOI: 10.1007/978-1-4939-7531-0_10

Abstract

In vivo Magnetic Resonance Spectroscopy (MRS) allows the non-invasive detection and quantification of a number of metabolites from localized volumes within a living organism. MRS localization techniques can be divided into two main groups, single voxel and multi-voxel. Single voxel techniques provide the metabolic profile from a specific small volume, whereas multi-voxel techniques are used to obtain the spatial distribution of metabolites throughout a large volume subdivided into small contiguous voxels. This chapter describes standard protocols for the acquisition and processing of in vivo single voxel¹H MRS data from the rodent brain.

Keywords: 1H MRS; Brain metabolites; Localized spectroscopy; Single voxel.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / metabolism*
Functional Neuroimaging / methods*
Hydrogen / metabolism*
Image Processing, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Proton Magnetic Resonance Spectroscopy / methods*
Rodentia

Substances

Hydrogen