Marine seaweeds contain a valuable source of functional bioactive polysaccharide and it plays main role for effective anticancer activity. The structural feature of SPs was studied through FT-IR and 1H NMR spectra analysis. The isolated SPs from A. spicifera contain 63.3% of total sugar, 21.9% of total sulfate and 12.6% of total uranic acid was found. The active F2 fraction molecular weight of SP was found to be 420 kDa. The sugar was composed of galactose (73.5%), xylose (9.2%), mannose (1.9%) and arabinose (10.9%). Further the SP showed DPPH free radical scavenging activity of 55.55% at 150 μg/mL and reducing power activity of 91.3% at 125 μg/mL. In the present study, the purified sulfated polysaccharide (fraction F2) were extracted, purified and characterized for red seaweed and evaluated for their potential anticancer activity of in A549 cell lines under in vitro condition. These polysaccharide fractions exhibited potential apoptotic effects on A549 cell lines.
Keywords: Acanthophora spicifera; Anticancer activity; Antioxidant activity; Sulfated polysaccharide.
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