[Myelodysplastic syndrome with refractory hemorrhage due to reduced platelet aggregation activity]

Rinsho Ketsueki. 2017;58(12):2402-2405. doi: 10.11406/rinketsu.58.2402.
[Article in Japanese]

Abstract

A 75-year-old woman suffered a cat bite 10 months after myelodysplastic syndrome (MDS) diagnosis. She visited our hospital because the internal bleeding of the wound did not improve. Although the wound was treated, the bleeding did not stop. She was hospitalized for emergency medical treatment because the bleeding volume exceeded 200 ml. Although her platelet count was normal, the platelet function test showed a decrease in collagen and arachidonic acid aggregation. After platelet transfusion, her bleeding stopped. Patients with MDS may potentially have platelet dysfunction. In the case of bleeding without thrombocytopenia, a platelet function test should be performed and treatment intervention, such as platelet transfusion, should be considered.

Keywords: Major bleeding; Myelodysplastic syndrome; Platelet dysfunction.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Blood Platelet Disorders / etiology*
  • Blood Transfusion
  • Female
  • Hemorrhage / etiology
  • Hemorrhage / therapy*
  • Humans
  • Myelodysplastic Syndromes / complications*
  • Platelet Aggregation
  • Treatment Outcome