Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis

Shi-Fei Li; Shun-Lin Li

doi:10.1016/S1875-5364(18)30012-8

Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis

Chin J Nat Med. 2017 Dec;15(12):950-954. doi: 10.1016/S1875-5364(18)30012-8.

Authors

Shi-Fei Li¹, Shun-Lin Li²

Affiliations

¹ Institute of Molecular Science, Shanxi University, Taiyuan 030006, China. Electronic address: lisf@sxu.edu.cn.
² State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: lisl@mail.kib.ac.cn.

PMID: 29329653
DOI: 10.1016/S1875-5364(18)30012-8

Abstract

In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C (1) and its glucoside, cycloccidentaliside VI (2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC₅₀ value of 1.44 μmol·L^-1 and TI (Therapeutic Index) value of 15.59.

Keywords: Cassia occidentalis; Cycloartane triterpenoid; Cycloccidentalic acid C; Cycloccidentaliside VI.

MeSH terms

Anti-HIV Agents / isolation & purification
Anti-HIV Agents / pharmacology
Cell Line, Tumor
Cell Survival / drug effects*
Glucosides / chemistry
Glucosides / pharmacology
Glucosides / toxicity
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Extracts / chemistry
Plant Extracts / isolation & purification
Plant Extracts / pharmacology*
Plant Extracts / toxicity
Senna Plant / chemistry*
Triterpenes / chemistry
Triterpenes / isolation & purification
Triterpenes / pharmacology*
Triterpenes / toxicity

Substances

Anti-HIV Agents
Glucosides
Plant Extracts
Triterpenes
cycloartane