Aerobic Photooxidative Synthesis of β-Alkoxy Monohydroperoxides Using an Organo Photoredox Catalyst Controlled by a Base

Yuya Asano; Yoshitomo Nagasawa; Eiji Yamaguchi; Akichika Itoh

doi:10.1002/asia.201701742

Aerobic Photooxidative Synthesis of β-Alkoxy Monohydroperoxides Using an Organo Photoredox Catalyst Controlled by a Base

Chem Asian J. 2018 Feb 16;13(4):409-412. doi: 10.1002/asia.201701742. Epub 2018 Feb 1.

Authors

Yuya Asano¹, Yoshitomo Nagasawa¹, Eiji Yamaguchi¹, Akichika Itoh¹

Affiliation

¹ Department of Organic and Medicinal Chemistry, Gifu Pharmaceutical University, Gifu Pharmaceutical University 1-25-4, Daigaku-nishi, Gifu, 501-1196, Japan.

PMID: 29327427
DOI: 10.1002/asia.201701742

Abstract

Transition-metal-free synthesis of β-alkoxy monohydroperoxides via aerobic photooxidation using an acridinium photocatalyst was developed. This method enables the synthesis of some novel hydroperoxides. The peroxide source is molecular oxygen, which is cost-effective and atomically efficient. Magnesium oxide plays an important role as a base in the catalytic system.

Keywords: acridinium catalyst; alkenes; hydroperoxide synthesis; oxygen; photocatalysis.