Van't Hoff analysis in chiral chromatography

Leonid D Asnin; Maria V Stepanova

doi:10.1002/jssc.201701264

Van't Hoff analysis in chiral chromatography

J Sep Sci. 2018 Mar;41(6):1319-1337. doi: 10.1002/jssc.201701264. Epub 2018 Jan 31.

Authors

Leonid D Asnin¹, Maria V Stepanova¹

Affiliation

¹ Department of Chemistry and Biotechnology, Perm National Research Polytechnic University, Perm, Russia.

PMID: 29323775
DOI: 10.1002/jssc.201701264

Abstract

The present review discusses the theory and application of van't Hoff analysis in chiral chromatography, with main focus on liquid chromatography. The topics considered include the physical meaning of van't Hoff equation's parameters, interpretation of thermodynamic data in terms of retention and enantioseparation mechanisms, abnormal behavior of van't Hoff plots, and best practices to avoid biased results.

Keywords: Van't Hoff plot; adsorption thermodynamics; chiral chromatography.

Publication types

Review