Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy

Chem Commun (Camb). 2018 Jan 25;54(9):1057-1060. doi: 10.1039/c7cc08222c.

Abstract

Stellated fibrous mesoporous silica nanospheres significantly improve the cellular uptake of cancer antigen and the maturation of bone marrow derived dendritic cells in vitro. Moreover, the combination of poly(I:C) with stellated fibrous MS nanospheres markedly decreases the necessary dose of poly(I:C) for anti-tumor immunity, and thus opens new opportunities for the future clinical application of poly(I:C) in cancer immunotherapy.

MeSH terms

  • Dendritic Cells / immunology
  • Humans
  • Immunotherapy / methods*
  • Neoplasms / immunology*
  • Neoplasms / therapy*
  • Particle Size
  • Poly I-C / administration & dosage
  • Poly I-C / chemistry
  • Poly I-C / immunology*
  • Porosity
  • RNA, Double-Stranded / chemical synthesis*
  • RNA, Double-Stranded / chemistry
  • RNA, Double-Stranded / immunology*
  • Silicon Dioxide / chemistry*
  • Surface Properties

Substances

  • RNA, Double-Stranded
  • Silicon Dioxide
  • Poly I-C