Abstract
Stellated fibrous mesoporous silica nanospheres significantly improve the cellular uptake of cancer antigen and the maturation of bone marrow derived dendritic cells in vitro. Moreover, the combination of poly(I:C) with stellated fibrous MS nanospheres markedly decreases the necessary dose of poly(I:C) for anti-tumor immunity, and thus opens new opportunities for the future clinical application of poly(I:C) in cancer immunotherapy.
MeSH terms
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Dendritic Cells / immunology
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Humans
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Immunotherapy / methods*
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Neoplasms / immunology*
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Neoplasms / therapy*
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Particle Size
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Poly I-C / administration & dosage
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Poly I-C / chemistry
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Poly I-C / immunology*
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Porosity
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RNA, Double-Stranded / chemical synthesis*
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RNA, Double-Stranded / chemistry
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RNA, Double-Stranded / immunology*
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Silicon Dioxide / chemistry*
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Surface Properties
Substances
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RNA, Double-Stranded
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Silicon Dioxide
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Poly I-C