Aldehyde-functionalized metal-organic frameworks for selective sensing of homocysteine over Cys, GSH and other natural amino acids

Jian Wang; Yanhong Liu; Min Jiang; Yang Li; Lingling Xia; Pengyan Wu

doi:10.1039/c7cc08414e

Aldehyde-functionalized metal-organic frameworks for selective sensing of homocysteine over Cys, GSH and other natural amino acids

Chem Commun (Camb). 2018 Jan 23;54(8):1004-1007. doi: 10.1039/c7cc08414e.

Authors

Jian Wang¹, Yanhong Liu, Min Jiang, Yang Li, Lingling Xia, Pengyan Wu

Affiliation

¹ School of Chemistry and Materials Science & Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China. wpyan@jsun.edu.cn.

PMID: 29323380
DOI: 10.1039/c7cc08414e

Abstract

A novel aldehyde-functionalized porous metal-organic framework (MOF) material has been constructed that can act as the first example of MOF-implicated sensors for discriminating Hcy from natural amino acids and even thiol-related peptides (GSH) with high sensitivity (LOD = 40 nM). The sensing mechanism is also discussed.

MeSH terms

Aldehydes / chemistry*
Amino Acids / analysis*
Cysteine / analysis
Glutathione / analysis*
Homocysteine / analysis*
Metal-Organic Frameworks / chemical synthesis
Metal-Organic Frameworks / chemistry*
Models, Molecular
Molecular Structure

Substances

Aldehydes
Amino Acids
Metal-Organic Frameworks
Homocysteine
Glutathione
Cysteine