In Japan, where a super-aging society is realized, we are most concerned about healthy longevity, which would ascertain the wellness of people by improving their quality of life (QOL). In 2014, the Cabinet Office proposed a strategic innovation promotion programme, launching a national project for the development of the agricultural-forestry-fisheries food products with new functionalities for the next generation. In addition to focusing on a conventional prevention of lifestyle-associated metabolic syndromes, the project targets the scientific evidence of the activation of brain cognitive ability and the improvement of bodily locomotive function. The project also involves the analysis of the foods-sports interrelation of chronic importance, and the development of devices for the verification of QOL-associated maintenance of homeostasis. In this review, we provide an overview of these studies, with special reference to cognition as a case of the gut-brain axis which the author is particularly interested in.
Keywords: AGE: advanced glycation end products; BAT: brown adipose tissue; DHA: docosahexaenoic acid; EPA: eicosapentaenoic acid; Functional foods; LDL: low-density lipoprotein cholesterol; TGR5: G protein-coupled receptor 5; WAT: white adipose tissue; cognition; gut-brain axis; locomotion; quality of life.