Posttranslational Modifications of RAS Proteins

Cold Spring Harb Perspect Med. 2018 Nov 1;8(11):a031484. doi: 10.1101/cshperspect.a031484.

Abstract

The three human RAS genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting. The enzymes that catalyze the various PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the focus of this review.

Publication types

  • Review

MeSH terms

  • Acetylation
  • Amino Acid Sequence / genetics
  • Bacterial Toxins / genetics
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Protein Processing, Post-Translational / genetics*
  • Protein Transport / genetics
  • Proto-Oncogene Proteins p21(ras) / genetics
  • Reactive Oxygen Species / metabolism
  • Signal Transduction
  • Sumoylation / genetics
  • Ubiquitination / genetics
  • ras Proteins / genetics*

Substances

  • Bacterial Toxins
  • Intracellular Signaling Peptides and Proteins
  • KRAS protein, human
  • Reactive Oxygen Species
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins