Does platelet serotonin receptor supersensitivity accompany endogenous depression?

O S Brusov; B S Beliaev; A B Katasonov; G P Zlobina; M I Factor; R R Lideman

doi:10.1016/0006-3223(89)90190-x

Does platelet serotonin receptor supersensitivity accompany endogenous depression?

Biol Psychiatry. 1989 Feb 15;25(4):375-81. doi: 10.1016/0006-3223(89)90190-x.

Authors

O S Brusov¹, B S Beliaev, A B Katasonov, G P Zlobina, M I Factor, R R Lideman

Affiliation

¹ Institute of Clinical Psychiatry, All-Union Center for Mental Health of the Academy of Medical Science, Moscow, U.S.S.R.

PMID: 2930807
DOI: 10.1016/0006-3223(89)90190-x

Abstract

In a population of drug-free bipolar and unipolar depressed women, it was found that the concentration of serotonin sufficient to induce half-maximal shape change velocity in platelets is significantly (p less than 0.001) lower (0.13 +/- 0.0.04 microM) than that of closely matched controls (0.532 +/- 0.1 microM). This platelet concentration becomes higher after 1-3 months of antidepressant treatment (0.47 +/- 0.16 microM). Possible mechanisms for this up- or down-regulation of platelet serotonin receptor responsiveness are discussed.

MeSH terms

Adult
Antidepressive Agents / therapeutic use*
Bipolar Disorder / blood
Bipolar Disorder / drug therapy*
Blood Platelets / drug effects*
Carbazoles / therapeutic use
Depressive Disorder / blood
Depressive Disorder / drug therapy*
Female
Humans
Imipramine / therapeutic use
Male
Maprotiline / therapeutic use
Middle Aged
Platelet Aggregation / drug effects
Receptors, Serotonin / drug effects*
Serotonin / blood*

Substances

Antidepressive Agents
Carbazoles
Receptors, Serotonin
Maprotiline
Serotonin
Imipramine
pirlindole