Preoperative decolonization to reduce infections in urgent lower extremity repairs

Eur J Trauma Emerg Surg. 2018 Oct;44(5):787-793. doi: 10.1007/s00068-017-0896-1. Epub 2018 Jan 6.

Abstract

Purpose: Medical implants and surgical site infections (SSIs) can be a burden on both patients and healthcare systems with a significant rise in morbidity, mortality and costs. Preoperatively, our practice of a chlorohexidine gluconate (CHG) washcloth bath or solution shower was supplemented with nasal painting using povidone-iodine skin and nasal antiseptic (PI-SNA). We sought to measure the effectiveness in reducing SSIs in patients undergoing repair of lower extremity fractures.

Methods: A retrospective review of trauma patients undergoing orthopedic operations conducted at Conemaugh Memorial Medical Center from 10/1/2012 through 9/30/2016. The intervention period was 10/1/2014 to 9/30/2016 which included the addition of nasal painting with PI-SNA preoperatively. All patients were followed for 1 year prior to January 2013 and 30 or 90 days thereafter for the development of a SSI.

Results: The pre-intervention group consisted of 930 cases with a 1.1% infection rate (10 SSIs). The intervention group consisted of 962 cases with a 0.2% infection rate (2 SSIs). This observed difference was statistically significant (P = 0.020).

Conclusions: This retrospective review of a methicillin-resistant Staphylococcus aureus decolonization protocol using CHG bath/shower and PI-SNA nasal painting revealed a significant decrease in the infection rate of patients undergoing lower extremity fracture repairs. We recommend its use without contraindications, but recognize that additional investigations are necessary.

Keywords: Decolonization; Fractures; MRSA; Povidone-iodine; Surgical site infection; Trauma.

MeSH terms

  • Administration, Intranasal
  • Adult
  • Aged
  • Anti-Infective Agents, Local / administration & dosage*
  • Baths
  • Carrier State / drug therapy
  • Chlorhexidine / administration & dosage*
  • Female
  • Humans
  • Leg Injuries / surgery*
  • Male
  • Methicillin-Resistant Staphylococcus aureus
  • Middle Aged
  • Povidone-Iodine / administration & dosage*
  • Retrospective Studies
  • Staphylococcal Infections / microbiology*
  • Staphylococcal Infections / prevention & control*
  • Surgical Wound Infection / microbiology*
  • Surgical Wound Infection / prevention & control*

Substances

  • Anti-Infective Agents, Local
  • Povidone-Iodine
  • Chlorhexidine