Mechanistic modelling of drug release from multi-layer capsules

Abstract

We propose a novel in silico model for computing drug release from multi-layer capsules. The diffusion problem in such heterogeneous layer-by-layer composite medium is described by a system of coupled partial differential equations, which we solve analytically using separation of variables. In addition to the conventional partitioning and mass transfer interlayer conditions, we consider a surface finite mass transfer resistance, which corresponds to the case of a coated capsule. The drug concentration in the core and through all the layers, as well as in the external release medium, is given in terms of a Fourier series that we compute numerically to describe and characterize the drug release mechanism.

Keywords: Diffusion equations; Drug release; Multi-layer capsules; Pharmacokinetics.