Activity-based sensing fluorescent probes for iron in biological systems

Allegra T Aron; Audrey G Reeves; Christopher J Chang

doi:10.1016/j.cbpa.2017.12.010

Activity-based sensing fluorescent probes for iron in biological systems

Curr Opin Chem Biol. 2018 Apr:43:113-118. doi: 10.1016/j.cbpa.2017.12.010. Epub 2018 Jan 5.

Authors

Allegra T Aron¹, Audrey G Reeves¹, Christopher J Chang²

Affiliations

¹ Department of Chemistry, University of California, Berkeley, CA 94720, USA.
² Department of Chemistry, University of California, Berkeley, CA 94720, USA; Departments of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. Electronic address: chrischang@berkeley.edu.

Abstract

Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe²⁺ forms, can help identify its contributions to physiology, aging, and disease. In this review, we summarize recent developments in activity-based sensing (ABS) probes for fluorescence Fe²⁺ detection.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biomimetics
Epigenesis, Genetic
Ferrous Compounds / analysis*
Ferrous Compounds / metabolism
Fluorescent Dyes / chemistry*
Humans
Iron-Binding Proteins / analysis*
Iron-Binding Proteins / metabolism
Oxidation-Reduction
Oxidative Stress
Oxides / metabolism

Substances

Ferrous Compounds
Fluorescent Dyes
Iron-Binding Proteins
Oxides

Abstract

Publication types

MeSH terms

Substances

Grants and funding