Functional failure of TLR3 and its signaling components contribute to herpes simplex encephalitis

Matylda Barbara Mielcarska; Magdalena Bossowska-Nowicka; Felix Ngosa Toka

doi:10.1016/j.jneuroim.2017.12.011

Functional failure of TLR3 and its signaling components contribute to herpes simplex encephalitis

J Neuroimmunol. 2018 Mar 15:316:65-73. doi: 10.1016/j.jneuroim.2017.12.011. Epub 2017 Dec 18.

Authors

Matylda Barbara Mielcarska¹, Magdalena Bossowska-Nowicka², Felix Ngosa Toka³

Affiliations

¹ Division of Immunology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8 Str., 02-786 Warsaw, Poland. Electronic address: matylda_mielcarska@sggw.pl.
² Division of Immunology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8 Str., 02-786 Warsaw, Poland.
³ Division of Immunology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8 Str., 02-786 Warsaw, Poland; Center for Integrative Mammalian Research, Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts and Nevis.

PMID: 29305044
DOI: 10.1016/j.jneuroim.2017.12.011

Abstract

Herpes simplex encephalitis (HSE) is a severe neurological disease in children and adults caused by herpes simplex virus. This review discusses recent findings on the role of Toll-like receptor 3 (TLR3) deficiencies in the HSE development. Critical checkpoints in the TLR3 signaling that contribute to innate response are discussed, including the importance of TLR3 ligand recognition site and transportation in the cell. We also indicate unresolved issues in the TLR3 functioning that might lead to thorough understanding of immunity during HSE. Such a knowledge base will lead to discovery and design of a rationale therapeutic and preventive approach against HSE.

Keywords: HSE; HSV-1; HSV-2; Innate immunity; TLR3.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Encephalitis, Herpes Simplex / immunology*
Encephalitis, Herpes Simplex / metabolism
Humans
Immunity, Innate / immunology*
Signal Transduction / immunology*
Toll-Like Receptor 3 / immunology*
Toll-Like Receptor 3 / metabolism

Substances

TLR3 protein, human
Toll-Like Receptor 3