Abstract
Spatial and temporal control over DNA cleavage by photoactivated enediynes can be complemented by additional factors such as the release of internal strain, chelation, pH changes, intramolecular H-bonds, and substituent effects. This review presents design and reactivity of photoactivated enediynes/enynes and analyses the chemical, biological, and photophysical challenges in their applications.
Keywords:
Bergman cyclization; DNA cleavage; DNA damage; apoptosis; diradicals; enediynes; photoactivation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / pharmacology*
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Antibiotics, Antineoplastic / radiation effects
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Antibiotics, Antineoplastic / therapeutic use
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Cyclization / radiation effects
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DNA Damage / drug effects
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DNA Damage / radiation effects
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DNA, Neoplasm / chemistry
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DNA, Neoplasm / drug effects*
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DNA, Neoplasm / radiation effects
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Enediynes / chemistry
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Enediynes / pharmacology*
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Enediynes / radiation effects
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Enediynes / therapeutic use
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Humans
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Light
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Lysine / chemistry
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Molecular Structure
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Molecular Targeted Therapy / methods
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Neoplasms / drug therapy*
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Neoplasms / genetics
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Photochemotherapy / methods*
Substances
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Antibiotics, Antineoplastic
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DNA, Neoplasm
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Enediynes
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Lysine