Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry

J Biomed Opt. 2018 Jan;23(1):1-9. doi: 10.1117/1.JBO.23.1.016003.

Abstract

Observation of temperature-mediated phase transitions between lipid components of the adipose tissues has been performed by combined use of the Abbe refractometry and optical coherence tomography. The phase transitions of the lipid components were clearly observed in the range of temperatures from 24°C to 60°C, and assessed by quantitatively monitoring the changes of the refractive index of 1- to 2-mm-thick porcine fat tissue slices. The developed approach has a great potential as an alternative method for obtaining accurate information on the processes occurring during thermal lipolysis.

Keywords: Abbe refractometry; adipose tissue; heating; lipolysis; optical coherence tomography; phase transition; refractive index.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue* / chemistry
  • Adipose Tissue* / diagnostic imaging
  • Adipose Tissue* / physiology
  • Animals
  • Equipment Design
  • Lipolysis / physiology
  • Lipolysis / radiation effects
  • Refractometry / instrumentation
  • Refractometry / methods*
  • Swine
  • Tomography, Optical Coherence / instrumentation
  • Tomography, Optical Coherence / methods*