Mitochondria in non-alcoholic fatty liver disease

Inês C M Simões; Adriana Fontes; Paolo Pinton; Hans Zischka; Mariusz R Wieckowski

doi:10.1016/j.biocel.2017.12.019

Mitochondria in non-alcoholic fatty liver disease

Int J Biochem Cell Biol. 2018 Feb:95:93-99. doi: 10.1016/j.biocel.2017.12.019. Epub 2017 Dec 26.

Authors

Inês C M Simões¹, Adriana Fontes², Paolo Pinton³, Hans Zischka⁴, Mariusz R Wieckowski⁵

Affiliations

¹ Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteur 3 Str., 02-093 Warsaw, Poland.
² Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstraße 1, D-85764, Neuherberg, Germany.
³ Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
⁴ Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstraße 1, D-85764, Neuherberg, Germany; Institute of Toxicology and Environmental Hygiene, Technical University Munich, Biedersteiner Straße 29, D-80802 Munich, Germany.
⁵ Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteur 3 Str., 02-093 Warsaw, Poland. Electronic address: m.wieckowski@nencki.gov.pl.

PMID: 29288054
DOI: 10.1016/j.biocel.2017.12.019

Abstract

NAFLD is a common disease in Western society and ranges from steatosis to steatohepatitis and to end-stage liver disease. The molecular mechanisms that cause the progression of steatosis to severe liver damage are not fully understood. One suggested mechanism involves the oxidation of biomolecules by mitochondrial ROS which initiates a vicious cycle of exacerbated mitochondrial dysfunction and increased hepatocellular oxidative damage. This may ultimately pave the way for hepatic inflammation and liver failure. This review updates our current understanding of mitochondria-derived oxidative stress in the progression of NAFLD.

Keywords: Mitochondria; NAFLD; NASH; ROS; Steatosis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Disease Progression
End Stage Liver Disease / etiology
Humans
Mitochondria, Liver / immunology
Mitochondria, Liver / metabolism*
Mitochondria, Liver / pathology
Non-alcoholic Fatty Liver Disease / immunology
Non-alcoholic Fatty Liver Disease / metabolism*
Non-alcoholic Fatty Liver Disease / pathology
Non-alcoholic Fatty Liver Disease / physiopathology
Oxidation-Reduction
Oxidative Stress*
Reactive Oxygen Species / metabolism*
Severity of Illness Index

Substances

Reactive Oxygen Species