Compartment diversity in innate immune reprogramming

Orhan Rasid; Jean-Marc Cavaillon

doi:10.1016/j.micinf.2017.12.008

Compartment diversity in innate immune reprogramming

Microbes Infect. 2018 Mar;20(3):156-165. doi: 10.1016/j.micinf.2017.12.008. Epub 2017 Dec 27.

Authors

Orhan Rasid¹, Jean-Marc Cavaillon²

Affiliations

¹ Chromatin and Infection, Institut Pasteur, Paris, France.
² Cytokines & Inflammation, Institut Pasteur, Paris, France. Electronic address: jean-marc.cavaillon@pasteur.fr.

PMID: 29287986
DOI: 10.1016/j.micinf.2017.12.008

Abstract

Pathogens or endogenous molecules can reprogram innate immunity. This process can take the form of priming or tolerance depending on the activating signal, and favors enhanced resistance to infection and other insults, by modulating inflammation. Similarly to their organ-specific properties, reprogramming of macrophages and NK cells, is also compartmentalized.

Keywords: BCG; Cytokines; DAMPs; Endotoxin; Innate immune memory; PAMPs.

Publication types

Review

MeSH terms

Animals
Cytokines / immunology
Cytokines / metabolism
Endotoxins / immunology*
Endotoxins / metabolism
Humans
Immunity, Innate / immunology*
Immunologic Memory / immunology*
Inflammation / immunology
Killer Cells, Natural / immunology
Macrophages / immunology
Organ Specificity / immunology*
Signal Transduction / immunology

Substances

Cytokines
Endotoxins