Neural stem cells in neuropsychiatric disorders

Roberto Sacco; Emanuele Cacci; Gaia Novarino

doi:10.1016/j.conb.2017.12.005

Neural stem cells in neuropsychiatric disorders

Curr Opin Neurobiol. 2018 Feb:48:131-138. doi: 10.1016/j.conb.2017.12.005. Epub 2017 Dec 26.

Authors

Roberto Sacco¹, Emanuele Cacci², Gaia Novarino³

Affiliations

¹ Institute of Science and Technology (IST) Austria, Klosterneuburg, Austria.
² Sapienza, University of Rome, Department of Biology and Biotechnology "Charles Darwin", Rome, Italy.
³ Institute of Science and Technology (IST) Austria, Klosterneuburg, Austria. Electronic address: mailto:gnovarino@ist.ac.at.

PMID: 29287246
DOI: 10.1016/j.conb.2017.12.005

Abstract

The precise control of neural stem cell (NSC) proliferation and differentiation is crucial for the development and function of the human brain. Here, we review the emerging links between the alteration of embryonic and adult neurogenesis and the etiology of neuropsychiatric disorders (NPDs) such as autism spectrum disorders (ASDs) and schizophrenia (SCZ), as well as the advances in stem cell-based modeling and the novel therapeutic targets derived from these studies.

Publication types

Review

MeSH terms

Animals
Autism Spectrum Disorder / pathology*
Autism Spectrum Disorder / therapy*
Cell Differentiation / physiology
Cell Proliferation / physiology
Humans
Neural Stem Cells / physiology*
Neural Stem Cells / transplantation
Neurogenesis / physiology
Schizophrenia / pathology*
Schizophrenia / therapy*