Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

Jin-Tang Cheng; Shi-Tao Chen; Cong Guo; Meng-Jiao Jiao; Wen-Jin Cui; Shu-Hui Wang; Zhe Deng; Chang Chen; Sha Chen; Jun Zhang; An Liu

doi:10.1007/s13659-017-0148-4

Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

Nat Prod Bioprospect. 2018 Feb;8(1):47-56. doi: 10.1007/s13659-017-0148-4. Epub 2017 Dec 29.

Authors

Jin-Tang Cheng¹, Shi-Tao Chen¹, Cong Guo¹, Meng-Jiao Jiao¹, Wen-Jin Cui¹, Shu-Hui Wang¹, Zhe Deng¹, Chang Chen¹, Sha Chen¹, Jun Zhang¹, An Liu²

Affiliations

¹ Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
² Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China. la62@163.com.

Abstract

Six new triterpenoid saponins, aesculusosides A-F (1-6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay, and compounds 15, 16, 19, and 23-25 exhibited inhibitory activities against MCF-7 with IC₅₀ values ranging from 7.1 to 31.3 μM.

Keywords: Aesculus chinensis; Anti-tumor activity; Chemical structures; Triterpenoid saponins.