Abstract
A growing body of studies has documented the pathological influence of impaired alternative splicing (AS) events on numerous diseases, including cancer. In addition, the generation of alternatively spliced isoforms is frequently noted to result in drug resistance in many cancer therapies. To gain comprehensive insights into the impacts of AS events on cancer biology and therapeutic developments, this paper highlights recent findings regarding the therapeutic routes of targeting alternative-spliced isoforms and splicing regulators to treatment strategies for distinct cancers.
Keywords:
alternative splicing; oligonucleotide; small molecule.
MeSH terms
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Adaptor Proteins, Signal Transducing / antagonists & inhibitors
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism
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Alternative Splicing / drug effects*
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Antineoplastic Agents / therapeutic use*
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Carcinogenesis / drug effects
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Carcinogenesis / metabolism
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Carcinogenesis / pathology
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Caspase 9 / genetics
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Caspase 9 / metabolism
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Cyclin D1 / antagonists & inhibitors
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Cyclin D1 / genetics
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Cyclin D1 / metabolism
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Cyclohexylamines / therapeutic use
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Epoxy Compounds / therapeutic use
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Humans
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Macrolides / therapeutic use
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Neoplasm Proteins / antagonists & inhibitors*
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism
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Neoplasms / genetics
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Neoplasms / metabolism
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Neoplasms / pathology
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Neoplasms / therapy*
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Nuclear Proteins / antagonists & inhibitors
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Oligonucleotides / genetics
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Oligonucleotides / metabolism
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Oligonucleotides / therapeutic use
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Pyrans / therapeutic use
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RNA Splicing Factors / antagonists & inhibitors*
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RNA Splicing Factors / genetics
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RNA Splicing Factors / metabolism
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RNA, Messenger / antagonists & inhibitors*
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Spiro Compounds / therapeutic use
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Spliceosomes / drug effects
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Spliceosomes / metabolism
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Tumor Suppressor Proteins / antagonists & inhibitors
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / metabolism
Substances
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5-((4-(5-(7,7-dimethyl-1,6-dioxaspiro(2.5)octan-5-yl)-3-methylpenta-2,4-dien-1-yl)cyclohexyl)amino)-5-oxopent-3-en-2-yl methylcarbamate
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Adaptor Proteins, Signal Transducing
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Antineoplastic Agents
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BIN1 protein, human
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CCND1 protein, human
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Cyclohexylamines
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Epoxy Compounds
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Macrolides
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Neoplasm Proteins
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Nuclear Proteins
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Oligonucleotides
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Pyrans
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RNA Splicing Factors
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RNA, Messenger
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Spiro Compounds
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Tumor Suppressor Proteins
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pladienolide B
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spliceostatin A
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Cyclin D1
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CASP9 protein, human
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Caspase 9