Neonatal screening for congenital CMV infection stresses the importance of maternal nonprimary infection even in an area where prenatal serology testing is common

J Matern Fetal Neonatal Med. 2019 Jun;32(11):1901-1904. doi: 10.1080/14767058.2017.1416605. Epub 2017 Dec 27.

Abstract

Aim and methods: Dried blood spots from 2149 newborns were examined to diagnose congenital cytomegalovirus (cCMV).

Results: Prenatal CMV-IgG antibodies had been measured during prenatal care in 1287 (60.3%) of mothers and 980 (76.1%) of them were found seropositive. cCMV incidence was 0.47%. All newborns were asymptomatic; 9/10 were born post nonprimary maternal infection; two developed sensorineural hearing loss.

Conclusions: In a country where prenatal CMV testing is common and therefore a false sense of control might prevail, nonprimary maternal infection should not be overlooked. Indeed, women of childbearing age should be educated on CMV prevention measures irrespectively to their serostatus.

Keywords: Congenital; cytomegalovirus; dried blood spot; nonprimary infection; sensorineural hearing loss.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Asymptomatic Infections / epidemiology
  • Cohort Studies
  • Cytomegalovirus Infections / congenital*
  • Cytomegalovirus Infections / epidemiology
  • Female
  • Greece / epidemiology
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Prevalence