Synthesis of [15 N]-cholamine bromide hydrobromide

J Labelled Comp Radiopharm. 2018 Apr;61(4):391-394. doi: 10.1002/jlcr.3598. Epub 2018 Mar 30.

Abstract

[15 N]-Cholamine is an isotope tag for metabolomics research, because it possesses 2 important properties: an NMR active isotope and a permanent charge for MS sensitivity. Here, we present a scalable synthesis of [15 N]-cholamine.

Keywords: [15N]-cholamine bromide hydrobromide; carboxylic acid metabolites; chemo-selective tag; smart isotope tag.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Bromides / chemistry
  • Carboxylic Acids / chemistry
  • Magnetic Resonance Spectroscopy / methods
  • Mass Spectrometry / methods
  • Nitrogen Isotopes / chemistry*
  • Trimethyl Ammonium Compounds / chemistry*

Substances

  • Bromides
  • Carboxylic Acids
  • Nitrogen Isotopes
  • Trimethyl Ammonium Compounds
  • cholamine