Comparative study between obstetric antiphospholipid syndrome and obstetric morbidity related with antiphospholipid antibodies
Med Clin (Barc). 2018 Sep 21;151(6):215-222.
doi: 10.1016/j.medcli.2017.11.017.
Epub 2017 Dec 20.
[Article in
English,
Spanish]
Authors
Jaume Alijotas-Reig
1
, Enrique Esteve-Valverde
2
, Raquel Ferrer-Oliveras
3
, Elisa LLurba
4
, Amelia Ruffatti
5
, Angela Tincani
6
, Elmina Lefkou
7
, Mª Tiziana Bertero
8
, Gerard Espinosa
9
, Sara de Carolis
10
, Patrizia Rovere-Querini
11
, Krista Lundelin
12
, Elisa Picardo
13
, Arsene Mekinian
14
; EUROAPS Study Group
Affiliations
- 1 Systemic Autoimmune Disease Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Department of Medicine, Universitat Autonoma, Barcelona, Spain. Electronic address: jalijotas@vhebron.net.
- 2 Internal Medicine Department, Althaia Healthcare Network of Manresa, Rheumatology Unit, Barcelona, Spain.
- 3 Obstetrics and Gynaecology Department, High Risk Unit, Vall d'Hebron University Hospital, Universitat Autonoma, Barcelona, Spain. Electronic address: raquelfo22@hotmail.com.
- 4 Obstetrics and Gynaecology Department, High Risk Unit, University Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 5 Rheumatology Unit, Department of Clinical and Experimental Medicine Azienda Ospedaliera, University of Padua, Padua, Italy.
- 6 Rheumatology and Clinical Immunology Unit, Ospedale Civile, Brescia, Italy.
- 7 Haematology Unit, Hippokration Hospital of Thessaloniki, Greece.
- 8 Department of Clinical Immunology, A.O. Mauriziano-Umberto I, Turin, Italy.
- 9 Systemic Autoimmune Diseases Service, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
- 10 Department of Gynaecology, Gemmeli Hospital, Catholic University, Roma, Italy.
- 11 Scuola di Specializzazione in Allergologia e Immunolofia Clinica, U.O. Medicina ad indrizzo Immunlogico Clinico-Ospedale San Raffaele, Milano, Lab, Autoimminità e inflammazione vascolare - San Raffaele DIBIT, Milano, Italy.
- 12 Internal Medicine Department, Hospital Universitario La Paz, Universidad Autònoma, Madrid, Spain.
- 13 Department of Obstetrics and Gynaecology, University of Turin, Turin, Italy.
- 14 AP-HP, Hôpital Saint-Antoine, service de médecine interne and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, F-75012, Paris, France.
Abstract
Background and objectives:
To compare clinical, laboratory, treatment and live birth rate data between women with aPL-related obstetric complications (OMAPS) not fulfilling the Sydney criteria and women fulfilling them (OAPS).
Materials and methods:
Retrospective and prospective multicentre study. Data comparison between groups from The European Registry on Antiphospholipid Syndrome included within the framework of the European Forum on Antiphospholipid Antibody projects.
Results:
338 women were analysed: 247 fulfilled the Sydney criteria (OAPS group) and 91 did not (OMAPS group). In the OMAPS group, 24/91 (26.37%) fulfilled laboratory Sydney criteria (subgroup A) and 67/91 (74.63%) had a low titre and/or non-persistent aPL-positivity (subgroup B). Overall, aPL laboratory categories in OAPS vs. OMAPS showed significant differences: 34% vs. 11% (p<0.0001) for category I, 66% vs. 89% (p<0.0001) for category II. No differences were observed when current obstetric complications were compared (p=0.481). 86.20% of OAPS women were treated vs. 75.82% of OMAPS (p=0.0224), particularly regarding the LDA+LMWH schedule (p=0.006). No differences between groups were observed in live births, gestational, puerperal arterial and/or venous thrombosis.
Conclusions:
Significant differences were found among aPL categories between groups. Treatment rates were higher in OAPS. Both OAPS and OMAPS groups had similarly good foetal-maternal outcomes when treated. The proposal to modify OAPS classification criteria, mostly laboratory requirements, is reinforced by these results.
Keywords:
Anticuerpos antifosfolípido; Antiphospholipid antibody; Antiphospholipid syndrome; Morbilidad obstétrica; Obstetric morbidity, Incomplete obstetric antiphospholipid syndrome; Registro; Registry; Síndrome antifosfolípido; Síndrome antifosfolípido obstétrico incompleto.
Copyright © 2017 Elsevier España, S.L.U. All rights reserved.
Publication types
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Comparative Study
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Multicenter Study
MeSH terms
-
Adult
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Antibodies, Antiphospholipid / blood*
-
Antiphospholipid Syndrome / diagnosis
-
Antiphospholipid Syndrome / therapy
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Female
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Humans
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Pregnancy
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Pregnancy Complications / blood*
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Pregnancy Complications / diagnosis
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Pregnancy Complications / immunology*
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Pregnancy Complications / therapy
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Prospective Studies
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Retrospective Studies
Substances
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Antibodies, Antiphospholipid