Impaired Th1 responses in patients with acute exacerbations of COPD are improved with PD-1 blockade

Clin Immunol. 2018 Mar:188:64-66. doi: 10.1016/j.clim.2017.12.007. Epub 2017 Dec 20.

Authors

Dino B A Tan¹, Teck-Hui Teo², Abdul M Setiawan², Nathanael E Ong³, Maja Zimmermann³, Alan Chen-Yu Hsu⁴, Peter A B Wark⁴, Yuben P Moodley⁵

Affiliations

¹ School of Biomedical Science, University of Western Australia, Nedlands, WA, Australia; Stem Cell Unit, Institute for Respiratory Health, Nedlands, WA, Australia. Electronic address: dino.tan@uwa.edu.au.
² School of Biomedical Science, University of Western Australia, Nedlands, WA, Australia.
³ Stem Cell Unit, Institute for Respiratory Health, Nedlands, WA, Australia.
⁴ Centre for Healthy Lungs, Hunter Medical Research Institute, University Newcastle, Newcastle, NSW, Australia.
⁵ School of Biomedical Science, University of Western Australia, Nedlands, WA, Australia; Stem Cell Unit, Institute for Respiratory Health, Nedlands, WA, Australia; Department of Respiratory and Sleep Medicine, Fiona Stanley Hospital, Perth, WA, Australia.

PMID: 29274389
DOI: 10.1016/j.clim.2017.12.007

No abstract available

Keywords: AECOPD; COPD; PD-1; T-cell.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Antibodies / immunology
Antibodies / pharmacology*
Female
Humans
Interferon-gamma / immunology
Interferon-gamma / metabolism
Interleukin-10 / immunology
Interleukin-10 / metabolism
Interleukin-6 / immunology
Interleukin-6 / metabolism
Male
Middle Aged
Programmed Cell Death 1 Receptor / antagonists & inhibitors*
Programmed Cell Death 1 Receptor / immunology
Programmed Cell Death 1 Receptor / metabolism
Pulmonary Disease, Chronic Obstructive / immunology*
Pulmonary Disease, Chronic Obstructive / metabolism
Pulmonary Disease, Chronic Obstructive / pathology
Th1 Cells / drug effects*
Th1 Cells / immunology
Th1 Cells / metabolism
Tumor Necrosis Factor-alpha / immunology
Tumor Necrosis Factor-alpha / metabolism

Substances

Antibodies
Interleukin-6
Programmed Cell Death 1 Receptor
Tumor Necrosis Factor-alpha
Interleukin-10
Interferon-gamma