On the Race to Starvation: How Do Bacteria Survive High Doses of Antibiotics?

Yusuf Talha Tamer; Erdal Toprak

doi:10.1016/j.molcel.2017.12.004

On the Race to Starvation: How Do Bacteria Survive High Doses of Antibiotics?

Mol Cell. 2017 Dec 21;68(6):1019-1021. doi: 10.1016/j.molcel.2017.12.004.

Authors

Yusuf Talha Tamer¹, Erdal Toprak²

Affiliations

¹ Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas TX, USA.
² Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas TX, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas TX, USA. Electronic address: erdal.toprak@utsouthwestern.edu.

PMID: 29272702
DOI: 10.1016/j.molcel.2017.12.004

Abstract

In this issue of Molecular Cell, Gutierrez et al. (2017) unravel a bacterial survival strategy that they term "density-dependent persistence" or DDP. The authors demonstrate that the majority of isogenic cells in bacterial populations survive lethal antibiotic doses once bacteria consume nutrients and enter stationary growth phase.

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MeSH terms

Anti-Bacterial Agents*
Bacteria*
Cell Cycle
Humans
Starvation

Substances

Anti-Bacterial Agents