Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

Chih-Yang Huang; Chia-Hua Kuo; Pei-Ying Pai; Tsung-Jung Ho; Yueh-Min Lin; Ray-Jade Chen; Fuu-Jen Tsai; V Vijaya Padma; Wei-Wen Kuo; Chih-Yang Huang

doi:10.1016/j.dib.2017.11.040

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

Data Brief. 2017 Nov 20:16:521-526. doi: 10.1016/j.dib.2017.11.040. eCollection 2018 Feb.

Authors

Chih-Yang Huang¹, Chia-Hua Kuo², Pei-Ying Pai³, Tsung-Jung Ho^{4

5}, Yueh-Min Lin^{6

7}, Ray-Jade Chen⁸, Fuu-Jen Tsai⁴, V Vijaya Padma⁹, Wei-Wen Kuo¹⁰, Chih-Yang Huang^{4

11

12}

Affiliations

¹ Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.
² Department of Sports Sciences, University of Taipei, Taipei, Taiwan.
³ Division of Cardiology, China Medical University Hospital, Taichung, Taiwan.
⁴ School of Chinese Medicine, China Medical University, Taichung, Taiwan.
⁵ Chinese Medicine Department, China Medical University Beigang Hospital, Taiwan.
⁶ Department of pathology, Changhua Christian Hospital, Changhua, Taiwan.
⁷ Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan.
⁸ Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁹ Department of Biotechnology, Bharathiar University, Coimbatore 641046, India.
¹⁰ Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
¹¹ Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
¹² Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.

Abstract

In association with the published article "Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy" (Huang et al., 2017) [1], this data article contains information about deSUMOylation of HSF2 on lysine 82 on angiotensin II (ANG II) -induced cardiac hypertrophy, which is mediated by MEL18. Isolated adult human whole heart tissue showed MEL18-mediated HSF2-IGF-IIR pathway is upregulated in hypertension human heart, compared to health human heart.