Implantable nanogenerators are rapidly advanced recently as a promising concept for harvesting biomechanical energy in vivo. This review article presents an overview of the most current progress of implantable piezoelectric nanogenerator (PENG) and triboelectric nanogenerator (TENG) with a focus on materials selection, engineering, and assembly. The evolution of the PENG materials is discussed from ZnO nanostructures, to high-performance ferroelectric perovskites, to flexible piezoelectric polymer mesostructures. Discussion of TENGs is focused on the materials and surface features of friction layers, encapsulation materials, and device integrations. Challenges faced by this promising technology and possible future research directions are also discussed.