United Again: STING and the Police

Darío Tejera; Michael T Heneka

doi:10.1016/j.neuron.2017.12.015

United Again: STING and the Police

Neuron. 2017 Dec 20;96(6):1207-1208. doi: 10.1016/j.neuron.2017.12.015.

Authors

Darío Tejera¹, Michael T Heneka²

Affiliations

¹ Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), 53127 Bonn, Germany.
² Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), 53127 Bonn, Germany. Electronic address: michael.heneka@ukbonn.de.

PMID: 29268089
DOI: 10.1016/j.neuron.2017.12.015

Abstract

Neuroinflammation is a common feature of aging and neurodegeneration. In this issue of Neuron, Mathur et al. (2017) report that the antiviral drug Ganciclovir induces an interferon type I response in microglia through activation of the STING pathway, inhibiting inflammation and leading to protection in a model of multiple sclerosis.

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MeSH terms

Animals
Inflammation
Interferon Type I*
Mice
Mice, Inbred C57BL
Microglia*
Police

Substances

Interferon Type I