Pathogenesis of Non-Zika Congenital Viral Infections

J Infect Dis. 2017 Dec 16;216(suppl_10):S912-S918. doi: 10.1093/infdis/jix431.

Abstract

A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 from South and Central America and the Caribbean. Although the full spectrum of ZIKV infection of the newborn has yet to be determined, other maternal viral infections resulting in transmission to the fetus provide instructive lessons that can be applied to the prospective evaluation of individuals with ZIKV infection. This review focuses on those other congenital infections, including rubella, congenital cytomegalovirus, human immunodeficiency virus, hepatitis B virus, and neonatal herpes simplex virus, from which lessons for the evaluation of ZIKV in the newborn can be applied.

Keywords: Zika; congenital infections; hepatitis B; neonatal herpes simplex infection; rubella.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Americas
  • Caribbean Region
  • Female
  • Hepatitis B / transmission
  • Hepatitis B / virology
  • Herpes Simplex / transmission
  • Herpes Simplex / virology
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / virology*
  • Pregnancy Complications, Infectious / virology
  • Rubella / transmission
  • Rubella / virology
  • Virus Diseases / transmission
  • Virus Diseases / virology*
  • Zika Virus / pathogenicity*
  • Zika Virus Infection / transmission
  • Zika Virus Infection / virology*

Supplementary concepts

  • Neonatal herpes