Process Improvement for Maximized Therapeutic Innovation Outcome

Clin Pharmacol Ther. 2018 Jan;103(1):8-12. doi: 10.1002/cpt.929.

Abstract

Deconvoluting key biological mechanisms forms the framework for therapeutic discovery. Strategies that enable effective translation of those insights along the development and regulatory path ultimately drive validated clinical application in patients and populations. Accordingly, parity in What vs. How we transform novel mechanistic insights into therapeutic paradigms is essential in achieving success. Aligning molecular discovery with innovations in structures and processes along the discovery-development-regulation-utilization continuum maximizes the return on public and private investments for next-generation solutions in managing health and disease.

Publication types

  • Editorial

MeSH terms

  • Diffusion of Innovation
  • Drug Discovery / methods*
  • Drug and Narcotic Control* / methods
  • Drug and Narcotic Control* / organization & administration
  • Humans
  • Medication Therapy Management / standards
  • Quality Improvement
  • Translational Research, Biomedical* / methods
  • Translational Research, Biomedical* / organization & administration