Retinal findings in membranoproliferative glomerulonephritis

Ahmad M Mansour; Luiz H Lima; J Fernando Arevalo; Miguel Hage Amaro; Virginia Lozano; Alaa Bou Ghannam; Errol W Chan

doi:10.1016/j.ajoc.2017.06.011

Retinal findings in membranoproliferative glomerulonephritis

Am J Ophthalmol Case Rep. 2017 Jun 22:7:83-90. doi: 10.1016/j.ajoc.2017.06.011. eCollection 2017 Sep.

Authors

Ahmad M Mansour^{1

2}, Luiz H Lima³, J Fernando Arevalo⁴, Miguel Hage Amaro⁵, Virginia Lozano⁶, Alaa Bou Ghannam¹, Errol W Chan⁷

Affiliations

¹ Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.
² Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon.
³ Department of Ophthalmology and Visual Sciences, Federal University of Sao Paulo, Sao Paulo, Brazil.
⁴ Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
⁵ Instituto de Olhos e Laser de Belém, Federal University of Sao Paulo, Sao Paulo, Brazil.
⁶ Department of Ophthalmology, Complejo Hospitalario Universitario de Canarias, Tenerife, Canary Islands, Spain.
⁷ Department of Ophthalmology, McGill University, Montreal, Canada.

Abstract

Purpose: To assess the evolution of retinal findings in patients with membranoproliferative glomerulonephritis (MPGN) by funduscopy, intravenous fluorescein angiography and optical coherence tomography.

Observations: Three women and one man were followed for a period of 1.5-37 years. Four patients (8 eyes) had drusen detected at first fundus exam at age 24, 29, 50 and 55. Three patients (6 eyes) had diffuse thickening of Bruch's membrane, and two patients (3 eyes) had detachment of the retinal pigment epithelium with serous retinal detachment. Drusen tended to widen over a period of 10-year follow-up in one case.

Conclusions and importance: Drusen remain the ocular stigmata for MPGN occuring at an early age. The retinal disease is progressive with gradual thickening of Bruch's membrane and occurrence of retinal pigment epithelium detachment.

Keywords: Drusen; Macular degeneration; Membranoproliferative glomerulonephritis; Retinal pigment epithelial detachment.

Publication types

Case Reports