Widespread application of water-saving measures, especially advanced drip irrigation technologies, may significantly impact on the land use, and further potentially alter regional ecological environments in an arid area. In this study, the remote sensing and geographic information system technology were used to analyze the LANDSAT images (1976-2015) and the MOD16 evapotranspiration data (2000-2015) in the Manas River Basin (MRB), China where the water-saving technologies have experienced the past 40 years. Our results show that the area of the cultivated land was approximately doubled from 1976 to 2015 with a dynamic degree of cultivated land ranging from 1.7% to 4%. The reclamation rates were estimated at 9.5% in 1976 and 21.8% in 2015 and the comprehensive index of land use degree shows an increasing trend in the MRB. The evapotranspiration in the MRB suggests that the cultivated land is becoming more humid while the other regions are becoming more arid. Long-term change in the land use is mainly promoted due to the multiple years' efforts on development of the water-saving technologies. This study greatly improves our understanding of the interactions between change in ecological environments and human activities and may provide policy makers guidance of sustainable development at an arid area.