ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview

Toxicon. 2018 Jul:149:65-71. doi: 10.1016/j.toxicon.2017.12.046. Epub 2017 Dec 16.

Abstract

ExoY is one of four well-characterized Pseudomonas aeruginosa type 3 secretion system (T3SS) effectors. It is a nucleotidyl cyclase toxin that is inactive inside the bacteria, but becomes potently activated once it is delivered into the eukaryotic target cells. Recently, filamentous actin was identified as the eukaryotic cofactor that stimulates specifically ExoY enzymatic activity by several orders of magnitude. In this review, we discuss recent advances in understanding the biochemistry of nucleotidyl cyclase activity of ExoY and its regulation by interaction with filamentous actin.

Keywords: Actin; Bacterial protein toxin; ExoY; Pseudomonas aeruginosa; T3SS.

Publication types

  • Review

MeSH terms

  • Actin Cytoskeleton / chemistry*
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / toxicity*
  • Eukaryotic Cells / microbiology
  • Glucosyltransferases / chemistry
  • Glucosyltransferases / toxicity*
  • Pseudomonas aeruginosa / chemistry*
  • Pseudomonas aeruginosa / enzymology
  • Pseudomonas aeruginosa / genetics

Substances

  • Bacterial Proteins
  • ExoY protein, bacteria
  • Glucosyltransferases