Regulatory T Cells Know What Is Needed to Regenerate

Christopher Jahn; Gilbert Weidinger

doi:10.1016/j.devcel.2017.12.010

Regulatory T Cells Know What Is Needed to Regenerate

Dev Cell. 2017 Dec 18;43(6):651-652. doi: 10.1016/j.devcel.2017.12.010.

Authors

Christopher Jahn¹, Gilbert Weidinger²

Affiliations

¹ Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
² Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. Electronic address: gilbert.weidinger@uni-ulm.de.

PMID: 29257945
DOI: 10.1016/j.devcel.2017.12.010

Abstract

Adaptive immunity has been suggested to limit regeneration in mammals. However, in this issue of Developmental Cell, Hui et al. (2017) report that regulatory T cells are required for regeneration of heart, spinal cord, and retina in the zebrafish. Intriguingly, in each organ system, T_reg cells secrete organ-specific regeneration factors.

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MeSH terms

Animals
Organogenesis
Regeneration
T-Lymphocytes, Regulatory
Zebrafish Proteins*
Zebrafish*

Substances

Zebrafish Proteins