Measuring procalcitonin to overcome heterophilic-antibody-induced spurious hypercalcitoninemia

Clin Chem Lab Med. 2018 Jul 26;56(8):e191-e193. doi: 10.1515/cclm-2017-0993.

Authors

Luca Giovanella^{1

2}, Ilaria Giordani³, Mauro Imperiali⁴, Fabio Orlandi³, Pierpaolo Trimboli¹

Affiliations

¹ Department of Nuclear Medicine and Competence Centre for Thyroid Disease, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
² School of Medicine, University of Zurich, Zurich, Switzerland.
³ Department of Endocrinology and Metabolism, University of Torino, Torino, Italy.
⁴ Department of Laboratory Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.

PMID: 29257751
DOI: 10.1515/cclm-2017-0993

No abstract available

Keywords: calcitonin; heterophilic antibodies; procalcitonin.

Publication types

Case Reports
Letter

MeSH terms

Aged
Antibodies, Heterophile / immunology
Calcitonin / blood*
Carcinoma, Neuroendocrine / diagnosis*
Cross Reactions
False Positive Reactions
Female
Humans
Immunoassay / methods
Middle Aged
Procalcitonin / blood*
Thyroid Neoplasms / diagnosis*

Substances

Antibodies, Heterophile
Procalcitonin
Calcitonin

Supplementary concepts

Thyroid cancer, medullary