Acute kidney injury and cholestasis associated with Kawasaki disease in a 9-year-old: Case report

Abstract

Kawasaki disease (KD) is a systemic vasculitis frequent in children younger than 5 years of age. It involves coronary arteries and other medium-sized vessels. There also exists evidence of inflammatory and proliferative changes affecting the biliary tract and lymphocyte infiltration of the renal interstitial. We describe the case of a 9-year-old girl who developed high-grade fever, bilateral non-purulent conjunctivitis, «strawberry» tongue, desquamation of the fingers and toes, cholestatic syndrome, edema and elevated serum creatinine. KD is a diagnostic challenge for the pediatrician. In every patient with high-grade fever, cholestasis and acute kidney injury, KD should be included in the differential diagnosis, even though more research is necessary to evaluate this atypical association.

Keywords: Acute kidney injury; Cholestasis; Colestasis; Daño renal agudo; Enfermedad de Kawasaki; Ictericia; Interstitial nephritis; Jaundice; Kawasaki disease; Nefritis intersticial.