Effect of beta-cypermethrin exposure on embryo implantation in mice

Reprod Toxicol. 2018 Mar:76:1-11. doi: 10.1016/j.reprotox.2017.12.001. Epub 2017 Dec 16.

Abstract

The aim of this study was to investigate the effect of β-CP on embryo implantation in mice. Forty female mice were randomly assigned to four groups of 10 mice each: one control group and three β-CP treated groups. The control group was administered corn oil only, while the three β-CP-treated groups were given corn oil containing 5, 10, and 20 mg/kg bw d β-CP for 3 months through intragastric administration. The results indicated that the administration of β-CP decreased the rate of embryo implantation (all p < 0.05), E2 level in the serum, and the expression of Homeobox A10 (HoxA10) protein. In addition, β-CP significantly increased ERa and PRA protein expression levels. These results suggest that β-CP can disrupt the balance of E2 and P, influence ERa and PRA expression and their downstream-related molecule Hoxa10, and decrease embryo implantation.

Keywords: Beta-cypermethrin; Embryo implantation; Mice; Toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Embryo Implantation / drug effects*
  • Endocrine Disruptors / toxicity*
  • Endometrium / drug effects
  • Endometrium / metabolism
  • Estradiol / blood
  • Estrogen Receptor alpha / biosynthesis
  • Female
  • Homeobox A10 Proteins
  • Homeodomain Proteins / biosynthesis
  • Male
  • Maternal Exposure / adverse effects*
  • Mice, Inbred Strains
  • Progesterone / blood
  • Pyrethrins / toxicity*
  • Receptors, Progesterone / biosynthesis

Substances

  • Endocrine Disruptors
  • Estrogen Receptor alpha
  • Homeobox A10 Proteins
  • Homeodomain Proteins
  • Pyrethrins
  • Receptors, Progesterone
  • progesterone receptor A
  • Hoxa10 protein, mouse
  • cypermethrin
  • Progesterone
  • Estradiol