Tackling Hypotheticals in Helminth Genomes

Abstract

Advancements in genome sequencing have led to the rapid accumulation of uncharacterized 'hypothetical proteins' in the public databases. Here we provide a community perspective and some best-practice approaches for the accurate functional annotation of uncharacterized genomic sequences.

Keywords: CRISPR; RNAi; annotation; genomes; helminth; hypothetical genes.