SPG5 siblings with different phenotypes showing reduction of 27-hydroxycholesterol after simvastatin-ezetimibe treatment

J Neurol Sci. 2017 Dec 15:383:39-41. doi: 10.1016/j.jns.2017.10.022. Epub 2017 Oct 16.

¹ Unit of Neurology and Neurometabolic Disorders, Department of Medicine, Surgery and Neurosciences, University of Siena, Italy. Electronic address: andrea.mignarri@teletu.it.
² Department of Paediatric Neuroscience, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy; Molecular Neurogenetics Unit, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy.
³ Department of Medicine and Surgery, Medical School, University of Milano-Bicocca, Italy.
⁴ Department of Neurology, Eastern Piedmont University, Novara, Italy.
⁵ Biochemistry and Genetics Laboratory, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy.
⁶ Unit of Diagnostic and Therapeutic Neuroradiology, Azienda Ospedaliera Siena, Italy.
⁷ Unit of Neurology and Neurometabolic Disorders, Department of Medicine, Surgery and Neurosciences, University of Siena, Italy.

No abstract available

Keywords: 27-hydroxycholesterol; Brain MRI; CYP7B1; Ezetimibe; Oxysterols; SPG5; Simvastatin.

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