Everyday cognitive failure and depressive symptoms predict fatigue in sarcoidosis: A prospective follow-up study

Celine Hendriks; Marjolein Drent; Willemien De Kleijn; Marjon Elfferich; Petal Wijnen; Jolanda De Vries

doi:10.1016/j.rmed.2017.11.008

Everyday cognitive failure and depressive symptoms predict fatigue in sarcoidosis: A prospective follow-up study

Respir Med. 2018 May:138S:S24-S30. doi: 10.1016/j.rmed.2017.11.008. Epub 2017 Nov 20.

Authors

Celine Hendriks¹, Marjolein Drent², Willemien De Kleijn³, Marjon Elfferich⁴, Petal Wijnen⁵, Jolanda De Vries⁶

Affiliations

¹ ILD Care Foundation Research Team, Ede, The Netherlands; Faculty of Medicine, Utrecht University, Utrecht, The Netherlands; ILD Center of Excellence, St. Antonius Hospital, Nieuwegein, The Netherlands.
² ILD Care Foundation Research Team, Ede, The Netherlands; ILD Center of Excellence, St. Antonius Hospital, Nieuwegein, The Netherlands; Dept. of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Science, Maastricht University, Maastricht, The Netherlands. Electronic address: m.drent@antoniusziekenhuis.nl.
³ ILD Care Foundation Research Team, Ede, The Netherlands; Dept. of Psychology and Artificial Intelligence, Radboud University, Nijmegen, The Netherlands.
⁴ ILD Care Foundation Research Team, Ede, The Netherlands.
⁵ ILD Care Foundation Research Team, Ede, The Netherlands; Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, The Netherlands.
⁶ ILD Care Foundation Research Team, Ede, The Netherlands; Dept. of Medical Psychology, St. Elisabeth Hospital Tilburg, Tilburg, The Netherlands; Dept. of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands.

PMID: 29239767
DOI: 10.1016/j.rmed.2017.11.008

Abstract

Background: Fatigue is a major and disabling problem in sarcoidosis. Knowledge concerning correlates of the development of fatigue and possible interrelationships is lacking.

Objective: A conceptual model of fatigue was developed and tested.

Methods: Sarcoidosis outpatients (n = 292) of Maastricht University Medical Center completed questionnaires regarding trait anxiety, depressive symptoms, cognitive failure, dyspnea, social support, and small fiber neuropathy (SFN) at baseline. Fatigue was assessed at 6 and 12 months. Sex, age, and time since diagnosis were taken from medical records. Pathways were estimated by means of path analyses in AMOS.

Results: Everyday cognitive failure, depressive symptoms, symptoms suggestive of SFN, and dyspnea were positive predictors of fatigue. Fit indices of the model were good.

Conclusions: The model validly explains variation in fatigue. Everyday cognitive failure and depressive symptoms were the most important predictors of fatigue. In addition to physical functioning, cognitive and psychological aspects should be included in the management of sarcoidosis patients.

Keywords: Anxiety; Cognition; Depressive symptoms; Fatigue; Quality of life (QoL); Sarcoidosis; Small fiber neuropathy (SFN); Social support.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anxiety / epidemiology
Anxiety / psychology
Cognitive Dysfunction / epidemiology
Cognitive Dysfunction / physiopathology
Cognitive Dysfunction / psychology*
Depression / epidemiology
Depression / psychology*
Dyspnea / epidemiology
Dyspnea / physiopathology
Fatigue / epidemiology
Fatigue / physiopathology
Fatigue / psychology*
Female
Follow-Up Studies
Forced Expiratory Volume
Humans
Lung / physiopathology
Male
Middle Aged
Prospective Studies
Pulmonary Diffusing Capacity
Quality of Life
Sarcoidosis / epidemiology
Sarcoidosis / physiopathology
Sarcoidosis / psychology*
Small Fiber Neuropathy / epidemiology
Small Fiber Neuropathy / physiopathology*
Social Support
Surveys and Questionnaires
Vital Capacity