Copper Catalysis and Organocatalysis Showing the Way: Synthesis of Selenium-Containing Highly Functionalized 1,2,3-Triazoles

Chem Rec. 2018 May;18(5):527-542. doi: 10.1002/tcr.201700058. Epub 2017 Dec 13.

Abstract

This article provides a comprehensive overview of reported methods - particularly copper- and organocatalyzed reactions - for the regioselective syntheses of selenium-containing 1,2,3-triazoles systems. These chemical entities are prevalent cores in biologically active compounds and functional materials. In view of their unique properties, substantial efforts have been paid for the design and development of practical approaches for the synthesis of these scaffolds.

Keywords: 1,2,3-triazoles; Selenium; click chemistry; copper; organocatalysis.

Publication types

  • Review

MeSH terms

  • Catalysis
  • Cell Line, Tumor
  • Click Chemistry
  • Copper / chemistry*
  • Cycloaddition Reaction
  • Humans
  • Organoselenium Compounds / chemical synthesis*
  • Organoselenium Compounds / pharmacology
  • Organoselenium Compounds / toxicity
  • Triazoles / chemical synthesis*
  • Triazoles / pharmacology
  • Triazoles / toxicity

Substances

  • Organoselenium Compounds
  • Triazoles
  • Copper