Imaging the glutamate receptor subtypes-Much achieved, and still much to do

Stefan Gruber; Simon M Ametamey

doi:10.1016/j.ddtec.2017.10.006

Imaging the glutamate receptor subtypes-Much achieved, and still much to do

Drug Discov Today Technol. 2017 Nov:25:27-36. doi: 10.1016/j.ddtec.2017.10.006. Epub 2017 Nov 8.

Authors

Stefan Gruber¹, Simon M Ametamey²

Affiliations

¹ Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, Zurich CH-8093, Switzerland.
² Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, Zurich CH-8093, Switzerland. Electronic address: simon.ametamey@pharma.ethz.ch.

PMID: 29233264
DOI: 10.1016/j.ddtec.2017.10.006

Abstract

Functional imaging of glutamate receptors using PET imaging modality can be used to study numerous CNS disorders and also to select appropriate doses of clinically relevant glutamate-receptor-targeting candidate drugs. Great strides have been made in developing PET imaging probes for the non-invasive detection of glutamate receptors in the brain. This review highlights recent progress made towards the development of glutamatergic PET imaging agents. Focus is placed on PET imaging probes that have been labelled with either carbon-11 or fluorine-18.

Publication types

Review

MeSH terms

Animals
Humans
Positron-Emission Tomography*
Protein Subunits / metabolism*
Receptors, Glutamate / metabolism*

Substances

Protein Subunits
Receptors, Glutamate